Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism

Inflammasomes are cytosolic caspase-1 activation complexes that sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic interactions by Pyrin domains (PYD) and caspase recruitment domains (CARD) in inflammasome component proteins mediate ol...

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Published in:Nat Struct Mol Biol
Main Authors: Lu, Alvin, Li, Yang, Schmidt, Florian I., Yin, Qian, Chen, Shuobing, Fu, Tian-Min, Tong, Alexander B., Ploegh, Hidde L., Mao, Youdong, Wu, Hao
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856535/
https://ncbi.nlm.nih.gov/pubmed/27043298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3199
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