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Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance

Microbiota has been shown to promote tolerogenic differentiation of T lymphocytes. It remains unclear to what extent microbiota triggers de novo re-programming or amplify pre-existing plasticity intrinsic to T cells. In a study with mouse models to track the clonal fate of CD4 and CD8 T cells, we di...

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Библиографические подробности
Опубликовано в: :Gut Microbes
Главные авторы: Lui, Jen Bon, McGinn, Lander S, Chen, Zhibin
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856445/
https://ncbi.nlm.nih.gov/pubmed/26939850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19490976.2015.1117737
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