Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

We have synthesized, separated, and purified approximately 10 mg of a deoxyundecanucleotide duplex containing a single centrally positioned covalent adduct between (+)-anti-benzo[a]pyrene (BP) diol epoxide and the exocyclic amino group of guanosine. Excellent proton NMR spectra are observed for the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cosman, M, de los Santos, C, Fiala, R, Hingerty, B E, Singh, S B, Ibanez, V, Margulis, L A, Live, D, Geacintov, N E, Broyde, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311854/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.5.1914
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