Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

We have synthesized, separated, and purified approximately 10 mg of a deoxyundecanucleotide duplex containing a single centrally positioned covalent adduct between (+)-anti-benzo[a]pyrene (BP) diol epoxide and the exocyclic amino group of guanosine. Excellent proton NMR spectra are observed for the...

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Main Authors: Cosman, M, de los Santos, C, Fiala, R, Hingerty, B E, Singh, S B, Ibanez, V, Margulis, L A, Live, D, Geacintov, N E, Broyde, S
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC48564/
https://ncbi.nlm.nih.gov/pubmed/1311854
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