IDH1(R132H) in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis

BACKGROUND: The high frequency of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in diffuse gliomas indicates its importance in the process of gliomagenesis. These mutations result in loss of the normal function and acquisition of the neomorphic activity converting α-ketoglutarate to 2-hydr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rosiak, Kamila, Smolarz, Maciej, Stec, Wojciech J., Peciak, Joanna, Grzela, Dawid, Winiecka-Klimek, Marta, Stoczynska-Fidelus, Ewelina, Krynska, Barbara, Piaskowski, Sylwester, Rieske, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856348/
https://ncbi.nlm.nih.gov/pubmed/27145078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154726
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