Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ

Arc/Arg3.1 gene product is rapidly upregulated by strong synaptic activity and critically contributes to weakening synapses by promoting AMPA-R endocytosis. However, how activity-induced Arc is redistributed and determines the synapses to be weakened remains unclear. Here, we show targeting of Arc t...

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Veröffentlicht in:Cell
Hauptverfasser: Okuno, Hiroyuki, Akashi, Kaori, Ishii, Yuichiro, Yagishita-Kyo, Nan, Suzuki, Kanzo, Nonaka, Mio, Kawashima, Takashi, Fujii, Hajime, Takemoto-Kimura, Sayaka, Abe, Manabu, Natsume, Rie, Chowdhury, Shoaib, Sakimura, Kenji, Worley, Paul F., Bito, Haruhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856149/
https://ncbi.nlm.nih.gov/pubmed/22579289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.062
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