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Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

Selective inhibitors of the type 1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against Escherichia coli infections such as urinary-tract infections. To construct these inhibitors, the α-d-mannopyranoside of high-mannose N-glycans, recogniz...

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Bibliografiske detaljer
Udgivet i:IUCrJ
Main Authors: de Ruyck, Jerome, Lensink, Marc F., Bouckaert, Julie
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856138/
https://ncbi.nlm.nih.gov/pubmed/27158502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252516002487
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