Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding

The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn’s disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-specific lectin domain connected via a pilin domain t...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Rabbani, Said, Krammer, Eva-Maria, Roos, Goedele, Zalewski, Adam, Preston, Roland, Eid, Sameh, Zihlmann, Pascal, Prévost, Martine, Lensink, Marc F., Thompson, Andrew, Ernst, Beat, Bouckaert, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331462/
https://ncbi.nlm.nih.gov/pubmed/28250938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252516016675
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