MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis

The TALE-class homeoprotein MEIS1 specifically collaborates with HOXA9 to drive myeloid leukemogenesis. Although MEIS1 alone has only a moderate effect on cell proliferation in vitro, it is essential for the development of HOXA9-induced leukemia in vivo. Here, using murine models of leukemogenesis,...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Yokoyama, Takashi, Nakatake, Mayuka, Kuwata, Takeshi, Couzinet, Arnaud, Goitsuka, Ryo, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Valk, Peter J.M., Delwel, Ruud, Nakamura, Takuro
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855920/
https://ncbi.nlm.nih.gov/pubmed/27018596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81516
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