Eosinophilic esophagitis–linked calpain 14 is an IL-13–induced protease that mediates esophageal epithelial barrier impairment

We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE) at 2p23 spanning the calpain 14 (CAPN14) gene, yet the causal mechanism has not been elucidated. We now show that recombinant CAPN14 cleaves a calpain-specific substrate and is inhibited by 4 classical calpain...

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Publicat a:JCI Insight
Autors principals: Davis, Benjamin P., Stucke, Emily M., Khorki, M. Eyad, Litosh, Vladislav A., Rymer, Jeffrey K., Rochman, Mark, Travers, Jared, Kottyan, Leah C., Rothenberg, Marc E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855700/
https://ncbi.nlm.nih.gov/pubmed/27158675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86355
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