Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity

Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus mediated by an IL-13–driven epithelial cell transcriptional program. Herein, we show that the cytoskeletal protein synaptopodin (SYNPO), previously associated with podocytes, is constitutively expressed in esophageal...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Rochman, Mark, Travers, Jared, Abonia, J. Pablo, Caldwell, Julie M., Rothenberg, Marc E.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846900/
https://ncbi.nlm.nih.gov/pubmed/29046486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96789
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