Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

Inactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tis...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Clausse, V, Goloudina, A R, Uyanik, B, Kochetkova, E Y, Richaud, S, Fedorova, O A, Hammann, A, Bardou, M, Barlev, N A, Garrido, C, Demidov, O N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855675/
https://ncbi.nlm.nih.gov/pubmed/27077811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.96
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