Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis

Conversion of intestinal stem cells into tumor-initiating cells is an early step in Apc(Min)-induced polyposis. Wild-type p53-induced phosphatase 1 (Wip1)-dependent activation of a DNA damage response and p53 has a permanent role in suppression of stem cell conversion, and deletion of Wip1 lowers th...

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Detalhes bibliográficos
Main Authors: Demidov, O N, Zhu, Y, Kek, C, Goloudina, A R, Motoyama, N, Bulavin, D V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469057/
https://ncbi.nlm.nih.gov/pubmed/22555459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.57
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