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Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis
Conversion of intestinal stem cells into tumor-initiating cells is an early step in Apc(Min)-induced polyposis. Wild-type p53-induced phosphatase 1 (Wip1)-dependent activation of a DNA damage response and p53 has a permanent role in suppression of stem cell conversion, and deletion of Wip1 lowers th...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469057/ https://ncbi.nlm.nih.gov/pubmed/22555459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.57 |
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