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An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem

BACKGROUND: The mutual exclusivity of somatic genome alterations (SGAs), such as somatic mutations and copy number alterations, is an important observation of tumors and is widely used to search for cancer signaling pathways or SGAs related to tumor development. However, one problem with current met...

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Detalles Bibliográficos
Publicado en:Algorithms Mol Biol
Main Authors: Lu, Songjian, Mandava, Gunasheil, Yan, Gaibo, Lu, Xinghua
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855522/
https://ncbi.nlm.nih.gov/pubmed/27148394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13015-016-0073-9
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