Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

Genetic ablation of CuZn-superoxide dismutase (Sod1) in mice (Sod1(−/−) mice) leads to shortened lifespan with a dramatic increase in hepatocellular carcinoma and accelerated aging phenotypes, including early onset sarcopenia. To study the tissue specific effects of oxidative stress in the Sod1(−/−)...

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Udgivet i:Mech Ageing Dev
Main Authors: Zhang, Yiqiang, Liu, Yuhong, Walsh, Michael, Bokov, Alex, Ikeno, Yuji, Jang, Young C., Perez, Viviana I., Van Remmen, Holly, Richardson, Arlan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855307/
https://ncbi.nlm.nih.gov/pubmed/26839948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2016.01.005
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