Exposure to Melan-A/MART-1(26-35) tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

Efficient processing of target antigens by the ubiquitin-proteasome-system (UPS) is essential for treatment of cancers by T cell therapies. However, immune escape due to altered expression of IFN-γ-inducible components of the antigen presentation machinery and consequent inefficient processing of HL...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Ebstein, Frédéric, Keller, Martin, Paschen, Annette, Walden, Peter, Seeger, Michael, Bürger, Elke, Krüger, Elke, Schadendorf, Dirk, Kloetzel, Peter-M., Seifert, Ulrike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855237/
https://ncbi.nlm.nih.gov/pubmed/27143649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25208
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