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Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) in men is an androgen-dependent neuromuscular disease caused by expanded CAG repeats in the androgen receptor (AR). Whether muscle or motor neuron dysfunction or both underlies motor impairment in SBMA is unknown. Muscles of SBMA mice show significant contra...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Xu, Youfen, Halievski, Katherine, Henley, Casey, Atchison, William D., Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Breedlove, S. Marc, Jordan, Cynthia L.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854970/
https://ncbi.nlm.nih.gov/pubmed/27147661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3485-15.2016
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