Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) in men is an androgen-dependent neuromuscular disease caused by expanded CAG repeats in the androgen receptor (AR). Whether muscle or motor neuron dysfunction or both underlies motor impairment in SBMA is unknown. Muscles of SBMA mice show significant contra...

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Publicado en:J Neurosci
Main Authors: Xu, Youfen, Halievski, Katherine, Henley, Casey, Atchison, William D., Katsuno, Masahisa, Adachi, Hiroaki, Sobue, Gen, Breedlove, S. Marc, Jordan, Cynthia L.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854970/
https://ncbi.nlm.nih.gov/pubmed/27147661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3485-15.2016
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