Automated synthesis of [(18)F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models

BACKGROUND: Prostate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various (18)F- and (68)Ga-labeled urea-based radiotracers for PET imaging of PSMA have been developed and entered clinical trials. Here, we describe an automated synthesis o...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Bouvet, Vincent, Wuest, Melinda, Jans, Hans-Soenke, Janzen, Nancy, Genady, Afaf R., Valliant, John F., Benard, Francois, Wuest, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854855/
https://ncbi.nlm.nih.gov/pubmed/27142881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0195-6
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