Competitive blocking of salivary gland [(18)F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

BACKGROUND: PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [(18)F]DCFPyL as a surrogate for PSMA-TRT, we report a novel meth...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Roy, Jyoti, Warner, Blake M., Basuli, Falguni, Zhang, Xiang, Zheng, Changyu, Goldsmith, Corrine, Phelps, Tim, Wong, Karen, Ton, Anita T., Pieschl, Rick, White, Margaret E., Swenson, Rolf, Chiorini, John A., Choyke, Peter L., Lin, Frank I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295433/
https://ncbi.nlm.nih.gov/pubmed/34287731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-021-00803-9
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