Competitive blocking of salivary gland [(18)F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

BACKGROUND: PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [(18)F]DCFPyL as a surrogate for PSMA-TRT, we report a novel meth...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EJNMMI Res
Prif Awduron: Roy, Jyoti, Warner, Blake M., Basuli, Falguni, Zhang, Xiang, Zheng, Changyu, Goldsmith, Corrine, Phelps, Tim, Wong, Karen, Ton, Anita T., Pieschl, Rick, White, Margaret E., Swenson, Rolf, Chiorini, John A., Choyke, Peter L., Lin, Frank I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2021
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295433/
https://ncbi.nlm.nih.gov/pubmed/34287731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-021-00803-9
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