Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis on FN gradients requires direct interaction betwee...

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Publicat a:Cancer Discov
Autors principals: Oudin, Madeleine J., Jonas, Oliver, Kosciuk, Tatsiana, Broye, Liliane C., Guido, Bruna C., Wyckoff, Jeff, Riquelme, Daisy, Lamar, John M., Asokan, Sreeja B., Whittaker, Charlie, Ma, Duanduan, Langer, Robert, Cima, Michael J., Wisinski, Kari B., Hynes, Richard O., Lauffenburger, Douglas A., Keely, Patricia J., Bear, James E., Gertler, Frank B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854754/
https://ncbi.nlm.nih.gov/pubmed/26811325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1183
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