Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

Findings from genetic, animal model, and human studies support the observation that accumulation of the β-amyloid (Aβ) peptide in the brain plays a central role in the pathogenic cascade of Alzheimer’s disease (AD). Human studies suggest that one key factor leading to accumulation is a defect in bra...

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Vydáno v:J Exp Med
Hlavní autoři: Yuede, Carla M., Lee, Hyo, Restivo, Jessica L., Davis, Todd A., Hettinger, Jane C., Wallace, Clare E., Young, Katherine L., Hayne, Margaret R., Bu, Guojun, Li, Chen-zhong, Cirrito, John R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854730/
https://ncbi.nlm.nih.gov/pubmed/27069115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151428
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