Crystal structure of ketopantoate reductase from Thermococcus kodakarensis complexed with NADP(+)

Coenzyme A (CoA) plays pivotal roles in a variety of metabolic pathways in all organisms. The biosynthetic pathway of CoA is strictly regulated by feedback inhibition. In the hyperthermophilic archaeon Thermococcus kodakarensis, ketopantoate reductase (KPR), which catalyzes the NAD(P)H-dependent red...

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Bibliographic Details
Published in:Acta Crystallogr F Struct Biol Commun
Main Authors: Aikawa, Yoshiki, Nishitani, Yuichi, Tomita, Hiroya, Atomi, Haruyuki, Miki, Kunio
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2016
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854564/
https://ncbi.nlm.nih.gov/pubmed/27139828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16005033
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