Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screenin...

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Udgivet i:Acta Crystallogr F Struct Biol Commun
Main Authors: Huschmann, Franziska U., Linnik, Janina, Sparta, Karine, Ühlein, Monika, Wang, Xiaojie, Metz, Alexander, Schiebel, Johannes, Heine, Andreas, Klebe, Gerhard, Weiss, Manfred S., Mueller, Uwe
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2016
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854561/
https://ncbi.nlm.nih.gov/pubmed/27139825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16004623
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