Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus

BACKGROUND: The current Japanese encephalitis (JE) vaccine derived from G3 JE virus (JEV) can induce protective immunity against G1–G4 JEV genotypes. However, protective efficacy against the emerging G5 genotype has not been reported. METHODS/PRINCIPAL FINDINGS: Using in vitro and in vivo tests, bio...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Cao, Lei, Fu, Shihong, Gao, Xiaoyan, Li, Minghua, Cui, Shiheng, Li, Xiaolong, Cao, Yuxi, Lei, Wenwen, Lu, Zhi, He, Ying, Wang, Huanyu, Yan, Jinghua, Gao, George Fu, Liang, Guodong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854478/
https://ncbi.nlm.nih.gov/pubmed/27139722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004686
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