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Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps. First, priming signals promote transcription of immature IL-1β and then, endogenous “danger” signals activate innate immune signaling complexes called inflammasomes...
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| 出版年: | Science |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854322/ https://ncbi.nlm.nih.gov/pubmed/26185250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa8064 |
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