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Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps. First, priming signals promote transcription of immature IL-1β and then, endogenous “danger” signals activate innate immune signaling complexes called inflammasomes...
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| Publié dans: | Science |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4854322/ https://ncbi.nlm.nih.gov/pubmed/26185250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa8064 |
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