Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations

BACKGROUND: Although genome-wide association studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA), our ability to translate these results into disease understanding and novel therapeutics is limited. Most RA GWAS loci reside outside of protein-coding regions...

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Publicado en:Genome Biol
Autores principales: Walsh, Alice M., Whitaker, John W., Huang, C. Chris, Cherkas, Yauheniya, Lamberth, Sarah L., Brodmerkel, Carrie, Curran, Mark E., Dobrin, Radu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853861/
https://ncbi.nlm.nih.gov/pubmed/27140173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0948-6
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