Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations

BACKGROUND: Although genome-wide association studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA), our ability to translate these results into disease understanding and novel therapeutics is limited. Most RA GWAS loci reside outside of protein-coding regions...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Walsh, Alice M., Whitaker, John W., Huang, C. Chris, Cherkas, Yauheniya, Lamberth, Sarah L., Brodmerkel, Carrie, Curran, Mark E., Dobrin, Radu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853861/
https://ncbi.nlm.nih.gov/pubmed/27140173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0948-6
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