Loss of IκB kinase β promotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop

Using forward and reverse genetics and global gene expression analyses, we explored the crosstalk between the IκB kinase β (IKKβ) and the transforming growth factor β (TGFβ) signaling pathways. We show that in vitro ablation of Ikkβ in fibroblasts led to progressive ROS accumulation and TGFβ activat...

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Enregistré dans:
Détails bibliographiques
Publié dans:Protein Cell
Auteurs principaux: Chen, Liang, Peng, Zhimin, Meng, Qinghang, Mongan, Maureen, Wang, Jingcai, Sartor, Maureen, Chen, Jing, Niu, Liang, Medvedovic, Mario, Kao, Winston, Xia, Ying
Format: Artigo
Langue:Inglês
Publié: Higher Education Press 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853320/
https://ncbi.nlm.nih.gov/pubmed/26946493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0241-6
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