Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis

A-kinase anchoring proteins (AKAPs) transmit signals cues from seven-transmembrane receptors to specific sub-cellular locations. Mitochondrial AKAPs encoded by the Akap1 gene have been shown to modulate mitochondrial function and reactive oxygen species (ROS) production in the heart. Under condition...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schiattarella, Gabriele Giacomo, Cattaneo, Fabio, Pironti, Gianluigi, Magliulo, Fabio, Carotenuto, Giuseppe, Pirozzi, Marinella, Polishchuk, Roman, Borzacchiello, Domenica, Paolillo, Roberta, Oliveti, Marco, Boccella, Nicola, Avvedimento, Marisa, Sepe, Maria, Lombardi, Assunta, Busiello, Rosa Anna, Trimarco, Bruno, Esposito, Giovanni, Feliciello, Antonio, Perrino, Cinzia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852950/
https://ncbi.nlm.nih.gov/pubmed/27136357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154076
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