Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis

A-kinase anchoring proteins (AKAPs) transmit signals cues from seven-transmembrane receptors to specific sub-cellular locations. Mitochondrial AKAPs encoded by the Akap1 gene have been shown to modulate mitochondrial function and reactive oxygen species (ROS) production in the heart. Under condition...

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Veröffentlicht in:PLoS One
Hauptverfasser: Schiattarella, Gabriele Giacomo, Cattaneo, Fabio, Pironti, Gianluigi, Magliulo, Fabio, Carotenuto, Giuseppe, Pirozzi, Marinella, Polishchuk, Roman, Borzacchiello, Domenica, Paolillo, Roberta, Oliveti, Marco, Boccella, Nicola, Avvedimento, Marisa, Sepe, Maria, Lombardi, Assunta, Busiello, Rosa Anna, Trimarco, Bruno, Esposito, Giovanni, Feliciello, Antonio, Perrino, Cinzia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852950/
https://ncbi.nlm.nih.gov/pubmed/27136357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154076
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