Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells

Here, we document that persistent mitochondria DNA (mtDNA) damage due to mitochondrial overexpression of the Y147A mutant uracil-N-glycosylase as well as mitochondrial overexpression of bacterial Exonuclease III or Herpes Simplex Virus protein UL12.5M185 can induce a complete loss of mtDNA (ρ(0) phe...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Spadafora, Domenico, Kozhukhar, Nataliya, Chouljenko, Vladimir N., Kousoulas, Konstantin G., Alexeyev, Mikhail F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852919/
https://ncbi.nlm.nih.gov/pubmed/27136098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154684
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