Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism

The ZFP36L3 protein is a rodent-specific, placenta- and yolk sac-specific member of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins. These proteins bind to AU-rich elements in target mRNAs, and promote their deadenylation and decay. We addressed the hypotheses that the absence o...

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Udgivet i:Development
Main Authors: Stumpo, Deborah J., Trempus, Carol S., Tucker, Charles J., Huang, Weichun, Li, Leping, Kluckman, Kimberly, Bortner, Donna M., Blackshear, Perry J.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852513/
https://ncbi.nlm.nih.gov/pubmed/26952984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.130369
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