Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis

The epithelial-to-mesenchymal transition (EMT) is a highly conserved morphogenetic program essential for embryogenesis, regeneration and cancer metastasis. In cancer cells, EMT also triggers cellular reprogramming and chemoresistance, which underlie disease relapse and decreased survival. Hence, ide...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Jimenez, Laura, Wang, Jindong, Morrison, Monique A., Whatcott, Clifford, Soh, Katherine K., Warner, Steven, Bearss, David, Jette, Cicely A., Stewart, Rodney A.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852498/
https://ncbi.nlm.nih.gov/pubmed/26794130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.021790
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