Pharmacological effects of two anti-methamphetamine monoclonal antibodies: Supporting data for lead candidate selection for clinical development

This lead candidate selection study compared two anti-(+)-methamphetamine (METH) monoclonal antibodies (mAb) to determine their ability to reduce METH-induced locomotor effects and redistribute METH and (+)-amphetamine (AMP) in a preclinical overdose model. Both mAbs have high affinity for METH, but...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Laurenzana, Elizabeth M, Stevens, Misty W, Frank, John C, Hambuchen, Michael D, Hendrickson, Howard P, White, Sarah J, Williams, D Keith, Owens, S Michael, Gentry, W Brooks
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852362/
https://ncbi.nlm.nih.gov/pubmed/25483484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.29707
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