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Treatment with a Monoclonal Antibody against Methamphetamine and Amphetamine Reduces Maternal and Fetal Rat Brain Concentrations in Late Pregnancy
We hypothesized that treatment of pregnant rat dams with a dual reactive monoclonal antibody (mAb4G9) against (+)-methamphetamine [METH; equilibrium dissociation rate constant (K(D)) = 16 nM] and (+)-amphetamine (AMP; K(D) = 102 nM) could confer maternal and fetal protection from brain accumulation...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109208/ https://ncbi.nlm.nih.gov/pubmed/24839971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.056879 |
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