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Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications
Cullin-RING ubiquitin ligases are the largest E3 ligase family in eukaryotes and are multiprotein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. To date, eight members of th...
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| Published in: | Front Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4852199/ https://ncbi.nlm.nih.gov/pubmed/27200299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00113 |
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