Inhibition of the Aryl Hydrocarbon Receptor Prevents Western Diet-Induced Obesity. Model for AHR Activation by Kynurenine via Oxidized-LDL, TLR2/4, TGFβ, and IDO1

Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed previously that the aryl hydrocarbon receptor (AHR) plays a role in the regulation of body mass in mice fed Western diet. The AHR is a ligand-ac...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Moyer, Benjamin J., Rojas, Itzel Y., Kerley-Hamilton, Joanna S., Hazlett, Haley F., Nemani, Krishnamurthy V., Trask, Heidi W., West, Rachel J., Lupien, Leslie E., Collins, Alan J., Ringelberg, Carol S., Gimi, Barjor, Kinlaw, William B., Tomlinson, Craig R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851598/
https://ncbi.nlm.nih.gov/pubmed/27020609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.03.011
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