Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

Cellular metabolites act as important signaling cues, but are subject to complex unknown chemistry. Kynurenine is a tryptophan metabolite that plays a crucial role in cancer and the immune system. Despite its atypical, non-ligand-like, highly polar structure, kynurenine activates the aryl hydrocarbo...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Seok, Seung-Hyeon, Ma, Zhi-Xiong, Feltenberger, John B., Chen, Hongbo, Chen, Hui, Scarlett, Cameron, Lin, Ziqing, Satyshur, Kenneth A., Cortopassi, Marissa, Jefcoate, Colin R., Ge, Ying, Tang, Weiping, Bradfield, Christopher A., Xing, Yongna
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808761/
https://ncbi.nlm.nih.gov/pubmed/29279331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000631
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