Inhibition of the Aryl Hydrocarbon Receptor Prevents Western Diet-Induced Obesity. Model for AHR Activation by Kynurenine via Oxidized-LDL, TLR2/4, TGFβ, and IDO1

Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed previously that the aryl hydrocarbon receptor (AHR) plays a role in the regulation of body mass in mice fed Western diet. The AHR is a ligand-ac...

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Publicado en:Toxicol Appl Pharmacol
Autores principales: Moyer, Benjamin J., Rojas, Itzel Y., Kerley-Hamilton, Joanna S., Hazlett, Haley F., Nemani, Krishnamurthy V., Trask, Heidi W., West, Rachel J., Lupien, Leslie E., Collins, Alan J., Ringelberg, Carol S., Gimi, Barjor, Kinlaw, William B., Tomlinson, Craig R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851598/
https://ncbi.nlm.nih.gov/pubmed/27020609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.03.011
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