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Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss
Alzheimer’s disease (AD) is characterized by neurofibrillary tangles, amyloid plaques, and neurodegeneration. However, this pathology is preceded by increased soluble amyloid beta (Aβ) 1−42 oligomers that interfere with the glutamatergic synaptic plasticity required for learning and memory, includin...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851299/ https://ncbi.nlm.nih.gov/pubmed/26957206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.103085 |
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