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AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
DNA deaminases underpin pathways in antibody diversification (AID) and anti-viral immunity (APOBEC3s). Here we show how a high-throughput bacterial papillation assay can be used to screen for AID mutants with increased catalytic activity. The upmutations focus on a small number of residues, some hig...
Tallennettuna:
| Julkaisussa: | Nat Struct Mol Biol |
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| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851237/ https://ncbi.nlm.nih.gov/pubmed/19543289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1623 |
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