Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells

BACKGROUND: Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for matrix metalloproteinase 9 (MMP-9) in kidney fibrosis via induction of epithelial-mesenchymal transition (EMT). Inhibition of MMP-...

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Gepubliceerd in:BMC Cell Biol
Hoofdauteurs: Zhao, Ye, Qiao, Xi, Wang, Lihua, Tan, Tian Kui, Zhao, Hong, Zhang, Yun, Zhang, Jianlin, Rao, Padmashree, Cao, Qi, Wang, Yiping, Wang, Ya, Wang, Yuan Min, Lee, Vincent W. S., Alexander, Stephen I., Harris, David C. H., Zheng, Guoping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850690/
https://ncbi.nlm.nih.gov/pubmed/27130612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-016-0101-0
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