Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages: IMPACT ON INTRACELLULAR SURVIVAL OF LEISHMANIA (VIANNIA) PANAMENSIS

Within its mammalian host, Leishmania resides and replicates as an intracellular parasite. The direct activity of antileishmanials must therefore depend on intracellular drug transport, metabolism, and accumulation within the host cell. In this study, we explored the role of human macrophage transpo...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Dohmen, Luuk C. T., Navas, Adriana, Vargas, Deninson Alejandro, Gregory, David J., Kip, Anke, Dorlo, Thomas P. C., Gomez, Maria Adelaida
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850301/
https://ncbi.nlm.nih.gov/pubmed/26903515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.688168
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