Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival

OBJECTIVES: Treatment failure is multifactorial. Despite the importance of host cell drug transporters and metabolizing enzymes in the accumulation, distribution and metabolism of drugs targeting intracellular pathogens, their impact on the efficacy of antileishmanials is unknown. We examined the co...

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Detalhes bibliográficos
Main Authors: Gómez, Maria Adelaida, Navas, Adriana, Márquez, Ricardo, Rojas, Laura Jimena, Vargas, Deninson Alejandro, Blanco, Victor Manuel, Koren, Roni, Zilberstein, Dan, Saravia, Nancy Gore
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861331/
https://ncbi.nlm.nih.gov/pubmed/23975742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt334
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