Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages: IMPACT ON INTRACELLULAR SURVIVAL OF LEISHMANIA (VIANNIA) PANAMENSIS

Within its mammalian host, Leishmania resides and replicates as an intracellular parasite. The direct activity of antileishmanials must therefore depend on intracellular drug transport, metabolism, and accumulation within the host cell. In this study, we explored the role of human macrophage transpo...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dohmen, Luuk C. T., Navas, Adriana, Vargas, Deninson Alejandro, Gregory, David J., Kip, Anke, Dorlo, Thomas P. C., Gomez, Maria Adelaida
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850301/
https://ncbi.nlm.nih.gov/pubmed/26903515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.688168
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