Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca(2+) Signaling

The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca(2+). Such fluxes are necessary for events like motility and egress from host cells. We used genetically encoded Ca(2+) indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulat...

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Foilsithe in:J Biol Chem
Main Authors: Sidik, Saima M., Hortua Triana, Miryam A., Paul, Aditya S., El Bakkouri, Majida, Hackett, Caroline G., Tran, Fanny, Westwood, Nicholas J., Hui, Raymond, Zuercher, William J., Duraisingh, Manoj T., Moreno, Silvia N. J., Lourido, Sebastian
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850295/
https://ncbi.nlm.nih.gov/pubmed/26933036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703546
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