Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca(2+) Signaling

The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca(2+). Such fluxes are necessary for events like motility and egress from host cells. We used genetically encoded Ca(2+) indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulat...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sidik, Saima M., Hortua Triana, Miryam A., Paul, Aditya S., El Bakkouri, Majida, Hackett, Caroline G., Tran, Fanny, Westwood, Nicholas J., Hui, Raymond, Zuercher, William J., Duraisingh, Manoj T., Moreno, Silvia N. J., Lourido, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850295/
https://ncbi.nlm.nih.gov/pubmed/26933036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703546
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