Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Hemolytic diseases, such as sickle cell anemia and thalassemia, are characterized by enhanced release of hemoglobin and heme into the circulation, heme-iron loading of reticulo-endothelial system macrophages, and chronic inflammation. Here we show that in addition to activating the vascular endothel...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Vinchi, Francesca, Costa da Silva, Milene, Ingoglia, Giada, Petrillo, Sara, Brinkman, Nathan, Zuercher, Adrian, Cerwenka, Adelheid, Tolosano, Emanuela, Muckenthaler, Martina U.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850229/
https://ncbi.nlm.nih.gov/pubmed/26675351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-08-663245
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