Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone

Regulation of energy balance by leptin involves regulation of several neuropeptides, including thyrotropin-releasing hormone (TRH). Synthesized from a larger inactive precursor, its maturation requires proteolytic cleavage by prohormone convertases 1 and 2 (PC1 and PC2). Since this maturation in res...

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Detalhes bibliográficos
Main Authors: Sanchez, Vanesa C., Goldstein, Jorge, Stuart, Ronald C., Hovanesian, Virginia, Huo, Lihong, Munzberg, Heike, Friedman, Theodore C., Bjorbaek, Christian, Nillni, Eduardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC484982/
https://ncbi.nlm.nih.gov/pubmed/15286802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421620
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